Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome

Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome

Blog Article

Obstructive sleep apnea syndrome (OSAS) is a serious, prevalent condition that has significant morbidity and mortality when untreated.It SABALASAN PROSTATE 1 is strongly associated with obesity and is characterized by changes in the serum levels or secretory patterns of several hormones.Obese patients with OSAS show a reduction of both spontaneous and stimulated growth hormone (GH) secretion coupled to reduced insulin-like growth factor-I (IGF-I) concentrations and impaired peripheral sensitivity to GH.Hypoxemia and chronic sleep fragmentation could affect the sleep-entrained prolactin (PRL) rhythm.

A disrupted Hypothalamus-Pituitary-Adrenal (HPA) axis activity has been described in OSAS.Some derangement in Thyroid-Stimulating Hormone (TSH) secretion has been demonstrated by some authors, whereas a normal thyroid activity has been described by others.Changes of gonadal axis are common in patients with OSAS, who frequently show a hypogonadotropic hypogonadism.Altogether, hormonal Rash Cream abnormalities may be considered as adaptive changes which indicate how a local upper airway dysfunction induces systemic consequences.

The understanding of the complex interactions between hormones and OSAS may allow a multi-disciplinary approach to obese patients with this disturbance and lead to an effective management that improves quality of life and prevents associated morbidity or death.